Your Liver and Cirrhosis
The liver carries out several necessary functions, including detoxifying harmful substances in your body, cleaning your blood, and making vital nutrients. The liver is your largest internal organ. About the size of a football, it is located mainly in the upper right portion of your abdomen, beneath the diaphragm and above your stomach.
A little scar tissue is not a problem for the liver, but too much scarring interferes with how the liver works, blocking the flow of blood through the liver, slowing the liver’s ability to process nutrients, and eventually compromising essential liver function. This can even lead to liver failure or death, with more than 40,000 people in the U.S. dying from cirrhosis each year.
Causes
Several things can damage the liver and cause cirrhosis. Some of the most common are chronic alcohol abuse and chronic infection with hepatitis B and hepatitis C viruses.
Other possible causes include:
Iron buildup in the body (hemochromatosis)Cystic fibrosisCopper accumulated in the liver (Wilson’s disease)Poorly formed bile ducts (biliary atresia)Inherited disorders of sugar metabolism (galactosemia or glycogen storage disease)Genetic digestive disorder (Alagille syndrome)Liver disease caused by your body’s immune system (autoimmune hepatitis)Destruction of the bile ducts (primary biliary cirrhosis)Hardening and scarring of the bile ducts (primary sclerosing cholangitis)Infection such schistosomiasisMedications such as methotrexate
Symptoms
Cirrhosis often has no signs or symptoms until liver damage is extensive. When signs and symptoms do occur, they may include:
FatigueBleeding easilyBruising easilyItchy skinYellow discoloration in the skin and eyes (jaundice)Fluid accumulation in your abdomen (ascites)Loss of appetiteNauseaSwelling in your legsWeight lossConfusion, drowsiness, and slurred speech (hepatic encephalopathy)Spiderlike blood vessels on your skinRedness in the palms of the handsTesticular atrophy in menBreast enlargement in men
Heavy Drinking, Cirrhosis, and Liver Disease
If you do not have liver disease, an occasional alcoholic drink probably won’t cause cirrhosis. However, heavy drinking (defined as having 8 or more drinks per week for women and 15 or more for men) is known to cause cirrhosis. This can develop into alcoholic liver disease.
If you have existing liver disease, such as chronic hepatitis, you are at increased risk for developing cirrhosis if you drink alcohol. Drinking alcohol may also increase your risk of developing hepatocellular cancer.
The liver damage caused by cirrhosis generally can’t be undone. But if liver cirrhosis is diagnosed early and the cause is treated, further damage can be limited and, rarely, reversed. If you already have cirrhosis, or if you have chronic hepatitis, it is important to avoid alcohol.
